Formation of pyrazine derivatives from D-glucosamine and their deoxyribonucleic acid(DNA) strand breakage activity.
نویسندگان
چکیده
منابع مشابه
Studies on pyrazine derivatives. XLVII. Synthesis and antibacterial activity of novel pyrazine derivatives with amidoxime moiety.
The new pyrazine derivatives exhibiting an antibacterial activity have been synthesized. Initial amidoxime 1 was obtained in the reaction of pyrazinecarbonitrile with hydroxylamine. Upon treatment of amidoxime with methyl iodide O-methyl derivative 2 was formed. Both amidoximes were transformed into imidoyl chlorides 3, 4. Then the chloride atom in those derivatives was substituted with various...
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Reactions of 1,3-propanediamine with alpha-dicarbonyl compounds (1a-e) were examined and various condensed heterocyclic compounds such as 1,4-diazepines (2) and 3-pyrimidine derivatives (3) were obtained. Some of 1,4-diazepines (2) showed DNA strand breakage activity.
متن کاملEnzymatic Breakage and Joining of Deoxyribonucleic Acid
Polynucleotide ligase from Escherichia coli infected with bacteriophage T4 catalyzes the esterification of interrupted phosphodiester bonds (single strand breaks) within a DNA duplex. Purified preparations of the enzyme also catalyze an isotopic exchange reaction between ATP and 3’PPi. However, they do not catalyze a measurable exchange between 3H-AMP and ATP. A radioactively labeled ligaseAMP ...
متن کاملSynthesis and Evaluation of Pyrazine Derivatives with Herbicidal Activity
The pyrazine ring is a part of many polycyclic compounds of biological and/or industrial significance; examples are quinoxalines, phenazines, and bio-luminescent natural products pteridines, flavins and their derivatives. All these compounds are characterized by a low lying unoccupied π-molecular orbital and by the ability to act as bridging ligand. Due to these two properties 1,4-diazines, and...
متن کاملPreparation and Evaluation anticancer activity of D-glucosamine Nanoparticles on Metastatic cancer Model in vivo
Objective(s): Breast cancer imposes a highest rate of malignancy among the women all around the world. Chitin and its derivatives such as D-glucosamine-carboxymethyl chitin and Di-hydroxy propyl chitin have immune-modulating effects and influence on innate and acquisitive immunity which lead to cell activity enhancement. The aim of this study was investigating the effect ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1991
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.39.792